![]() However, in some cases, depending on age and treatment history, triggering ovulation of 3 or more follicles may be warranted. While there is no definitive evidence regarding the exact number of follicles that increases the risk of a multiple pregnancy, most providers exhibit caution with 3 or more mature follicles. Triplets or more occur in less than 1% of IUI cycles.The risk of having a twin pregnancy following the use of injectable hormones and IUI is about 20%.The risk of having a twin pregnancy following use of oral ovulation induction agents is approximately 8%.The likelihood of having a multiple pregnancy also depends on the type of ovarian stimulation used: ![]() With a greater number of mature follicles, the risk of having a multiple pregnancy increases. As a result, there’s a higher chance of superovulation (ovulating more than one mature egg), and also fertilization of more than one egg. When fertility medications are used, it’s possible for more than one follicle to develop. What Are the Risks Associated with Ovarian Stimulation and IUI? Please note that IUI success rates vary by age and diagnosis. Following the procedure, you can resume daily activities. The procedure, which takes just a few minutes, is performed in the office using a small, flexible catheter that is placed into the uterine cavity. The sample is then washed so a high concentration of motile sperm is available for insemination. Prior to your IUI appointment, a semen sample is collected from your partner, or thawed if a frozen donor sperm sample is being used. Two weeks into your cycle, your fertility doctor will verify the number of mature follicles on ultrasound and determine if you are ready to take a human chorionic gonadotropin (hCG) injection, which triggers ovulation to occur approximately 36 hours later.Īfter taking the hCG, you will then be scheduled for an IUI appointment within that time frame. Oral medications such as Clomiphene Citrate (Clomid) or Letrozole, or injectable hormones like Gonal-F, Follistim or Menopur can be used to help if you do not ovulate, or if you ovulate infrequently. Here are more details on the procedure and the timing: Ovulation induction usually starts at the beginning of your menstrual cycle. How Does Ovulation Induction and IUI Work? It’s important that you understand the risks and know when it is appropriate to cancel an IUI cycle. However, even with careful monitoring, there are risks associated with ovarian stimulation and IUI that are not as common with more advanced reproductive technologies, like in vitro fertilization (IVF). If oral or injectable medication is used for ovulation induction, monitoring of your hormone levels and follicle growth may be necessary during your cycle. An IUI is often performed in conjunction with ovarian stimulation for ovulation induction, although it can also be done following a natural cycle. Intrauterine insemination (IUI) is a fertility treatment in which a concentrated sample of motile sperm is placed directly into the uterine cavity.
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